The Ministry of Health (MOH) of Cambodia conducted a Regional Workshop on Information and Communication Technology (ICT) for Surveillance System on 5–6 September 2019 at Somadevi Angkor Hotel in Siem Reap, Cambodia. The workshop, which was financed under Loan 3464-CAM: GMS Health Security Project (HSP) provided an opportunity for concerned officials of Ministries of Health (MOH) of Cambodia, Laos, Myanmar, and Viet Nam (CLMV) to share the current status, challenges, and solutions in applying ICT to improve the health systems in their country and develop an ICT regional plan for supporting health cooperation in the region. ICT focal persons from Ministries of Health of CLMV, officials/staff of Project Management Unit of HSP in CLMV, ADB consultants, and a representative of World Health Organization participated in this workshop.