The 10-year Strategic Framework of the Greater Mekong Subregion (GMS–SF) Economic Cooperation Program (GMS Program) was endorsed by the heads of the GMS-member governments during their first summit meeting held in Phnom Penh, Cambodia on 3 November 2002. Since then, the GMS–SF has guided the implementation of the GMS Program. In 2007, the GMS–SF is halfway through its implementation period. At the same time, significant changes affecting the GMS Program have been taking place in the regional and global environments. This Midterm Review of the GMS–SF (i) assesses whether the GMS–SF is still relevant and appropriate, considering the progress made and the changing regional and global environments; and (ii) puts forward recommendations to improve its overall impact.